A new strategy to block tumor growth by inhibiting endocannabinoid inactivation MAURIZIO BIFULCO * ,† ,1 , CHIARA LAEZZA * , MARTA VALENTI ‡ , ALESSIA LIGRESTI ‡ , GIUSEPPE PORTELLA * and VINCENZO DI MARZO ‡ ,1 Endocannabinoid Research Group, * Istituto di Endocrinologia ed Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, and Dipartimento di Biologia e Patologia Cellulare e Molecolare "L. Califano," Università di Napoli "Federico II", † Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Fisciano, Italy; and ‡ Istituto di Chimica Biomolecolare, C.N.R., Pozzuoli, Italy 1 Correspondence: E-mail: V.D.M., vdimarzo@icmib.na.cnr.it and M.B., maubiful@unina.it <h3>SPECIFIC AIMS</h3> Endocannabinoid signaling has been shown to be enhanced in several cancer tissues and malignant cells, and studies in cell lines have suggested that this up-regulation might provide transformed cells with a further means to inhibit their proliferation via more than one molecular mechanism. To provide evidence to this hypothesis and to search for possible novel antitumor therapeutic strategies, we investigated the effect of inhibitors of endocannabinoid degradation on the growth of rat thyroid tumor xenografts. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Inhibitors of endocannabinoid degradation inhibit rat thyroid tumor xenografts in vivo</h3> Substances were administered the first time together with subcutaneous inoculation
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A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
BIFULCO, MAURIZIO; LAEZZA, CHIARA; VALENTI, MARTA; LIGRESTI, ALESSIA; PORTELLA, GIUSEPPE; DI MARZO, VINCENZO
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, Volume 18 (13): 1606
Fed of American Socs for Experimental Biology – Oct 1, 2004
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