A new generation organ culture arising from cross-talk between multiple primary human cell types Manuela Martins-Green 1 , Qi-Jing Li 2 and Min Yao Department of Cell Biology and Neuroscience, University of California, Riverside, California, USA 1 Correspondence: Department of Cell Biology and Neuroscience, Spieth Hall, University of California Riverside, 900 University Ave., Riverside, CA 92521, USA. E-mail: mmgreen@ucrac1.ucr.edu <h3>SPECIFIC AIMS</h3> The inability to directly experiment with humans creates the need to develop culture systems that mimic human tissues and organs in order to understand biological processes. The availability of primary human cells now enables the engineering of such tissues and organs. The aim of this study was to develop an organ culture to allow investigation of physiological/pathological processes in a human tissue under conditions that are well controlled and yet mimic in vivo. <h3>PRINCIPAL FINDINGS</h3> The organ culture presented here was prepared by culturing together the three primary cell types of skin (fibroblasts, microvascular endothelial cells, and keratinocytes) in a basic extracellular matrix composed of interstitial collagen. This organ culture matures into a tissue that 1) contains a well-developed epidermis and a network of microvessels, 2) produces human cytokines, growth factors, and extracellular matrix (ECM) molecules characteristic
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A new generation organ culture arising from cross-talk between multiple primary human cell types
Martins-Green, Manuela; Li, Qi-Jing; Yao, Min
Follow The FASEB Journal
, Volume 19 (2): 222
Fed of American Socs for Experimental Biology – Feb 1, 2005
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