ABSTRACT Key Words: insecticidal toxin toxin evolution toxin interactions produce insecticidal toxins and are used to control mosquito vectors of human disease. These strains may produce mosquitocidal toxins named Mtx1, Mtx2, and Mtx3 during vegetative growth, but production levels are low and the proteins do not survive into the spores that are the active agent used in mosquito control (3â5). The major toxic moiety of commercial B. sphaericus strains is the spore-associated binary toxin (Bin), comprising two components; BinB that appears to have a major role in receptor binding (6 â 8) and BinA that is able to form pores in target membranes (9, 10). Although there is some evidence that BinA alone may be toxic in high doses (11), signiï¬cant toxicity requires the presence of both proteins and is optimal at a 1:1 M ratio (12). Despite the excellent performance of B. sphaericus in the ï¬eld, the presence of only the Bin toxin in spores has allowed insects to develop resistance (13â15) that may limit its application or necessitate rotation with other insecticides. To identify B. sphaericus strains that may cope with resistance, screening of various isolates resulted in the detection of strains producing spores that are
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A new Cry toxin with a unique two-component dependency from Bacillus sphaericus
Gareth W. Jones , Christina Nielsen-Leroux , Yankun Yang , Zhiming Yuan , Vinícius Fiúza Dumas , Rose Gomes Monnerat , and Colin Berry
Follow The FASEB Journal
, Volume 21 (14): 4112
Fed of American Socs for Experimental Biology – Dec 1, 2007
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