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A central role for inflammation in the pathogenesis of diabetic retinopathy ANTONIA M. JOUSSEN * ,† ,‡ ,§ ,1 , VASSILIKI POULAKI ‡ ,§ , MINH LY LE * , KAN KOIZUMI * , CHRISTINA ESSER * , HANNA JANICKI * , ULRICH SCHRAERMEYER * , NORBERT KOCIOK † , SASCHA FAUSER † , BERND KIRCHHOF * ,† , TIMOTHY S. KERN || and ANTHONY P. ADAMIS ‡ ,†† ,1 * Department of Vitreoretinal Surgery and Angiogenesis Laboratory, Center of Ophthalmology, † Center for Molecular Medicine (ZMMK) University of Cologne, Köln, Germany; ‡ Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, § Laboratory for Surgical Research, Children’s Hospital, Harvard Medical School, Boston, Massachusetts, USA; || Departments of Medicine and Ophthalmology and Center for Diabetes Research, Case Western Reserve University, Cleveland, Ohio, USA; and †† Eyetech Research Center, Woburn, Massachusetts, USA 1 Correspondence: A.M.J., Department of Vitreoretinal Surgery, Center for Ophthalmology, University of Cologne, Joseph Stelzmannstr. 9, 50924 Köln, Germany; E-mail: JoussenA@aol.com ; A.P.A., Eyetech Research Center, 42 Cummings Park, Woburn, MA 01801, USA; E-mail: tony.adamis@eyetk.com <h3>SPECIFIC AIMS</h3> Diabetic retinopathy, the leading cause of blindness, is characterized by early retinal microvascular dysfunction. As we have shown before, endothelial damage

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