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in neuronal versus non- neuronal models. Mn- induced neurotoxicity in rodent cell culture models In addition to clinical studies, rodent models are also widely used for the study of the mechanisms underlying Mn ...
-transport function,63 and may protect neurons from copper- induced neurotoxicity .64 When ATOX1 is oxidized due to a GSH/GSSG imbalance, there is a reduction in copper delivery to the secretory pathway ...
IACUC-approved protocols. Hippocampal neurons were plated at 1 × 105 cells/well onto nitric acid-washed, poly-d-lysine-coated 12 mm coverslips in 24 well plates then maintained 14 days in vitro (DIV ...
a novel mechanism underlying Al- induced neurotoxicity . aluminum, amyloid-β, Rho-ROCK, cultured cortical neurons Aluminum (Al) is environmentally abundant but not an essential element. Because Al has long ...
during the period of active microvessel growth. Rat pups become progressively resistant to lead- induced neurotoxic effects as they mature (Holtzman et al., 1982). Although neurons retain the ability ...
, and immunohistochemistry, and it was able to show the formation of projections and synaptic contacts between cortical and hippocampal neurons , thereby enabling in vitro investigations of interactions between multiple brain ...
antiproliferative compounds. The utility of this in vitro screen was evaluated further using a set of compounds containing eight known to cause developmental neurotoxicity and eight presumably nontoxic compounds. Six ...
system expressing human wildtype α-Syn was used to examine the roles of several early-onset PD-associated genes in mediating Mn- induced neurotoxicity . Introduction Parkinson's disease (PD) is the second ...
, La could cause [Ca2+]i overload and induce excitotoxicity, resulting in excessive apoptosis of neurons via the mitochondrial pathway.18 Despite this, the neurotoxicity mechanism of La has not been ...
transporter proteins. It is hypothesized that zinc released from the neurons can react with Aβ to facilitate aggregation82 as zinc can induce the precipitation of Aβ40.83 The precipitation of Aβ is considered ...
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