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mediated growth inhibition of AR+ prostate cancer cell lines. We have also sought the mechanism for anti‐ androgen mediated reversal of 1,25(OH)2D3 dependent growth inhibition in LNCaP cells . RESULTS Although ...
to androgen in these cells (10). Growth inhibition of LNCaP cells by 1,25-(OH)2D3 is mediated by an androgen -dependent mechanism and is preceded by the induction of AR gene expression (12). Furthermore, growth ...
disease. PC progression involves the shifting of cells from androgen -dependent growth to an androgen -independent state, sometimes with the loss or mutation of the androgen receptors in PC cells . Both ...
). Compounds that induce PTHrP production include fetal bovine serum (FBS) and a variety of growth factors, whereas dexamethasone and vitamin D suppress PTHrP in a number of cell types (23, 24). Normal prostate ...
. Loss of bone mineral density is an unintended consequence of androgen deprivation therapy in men with prostate cancer. Supplementation with calcium and/or vitamin D in these men seems logical ...
to the AR, thereby inducing the expression of multiple genes that regulate cell growth . Androgen ablation therapy is frequently used for treatment of recurrent prostate cancer. However, the majority of tumors ...
. Significantly, enhancing sortilin expression in PC3 and DU145 cells severely diminishes progranulin levels and inhibits motility, invasion, proliferation, and anchorage-independent growth . In addition, sortilin ...
. In fact, down‐regulation of the AR in a prostate carcinoma cell line caused growth inhibition (Eder et al., 2001), indicating that at least a survival signal is required through androgen signalling ...
agent [77]. The antiproliferative effects of 1,25 D3 are partly mediated by its binding to vitamin D receptors (VDR) found in prostate cancer cells . This is further supported by experimental evidence ...
studies demonstrated that δ-tocopherol (δ-T) attenuates the activation of AKT by growth factor in prostate cancer cell lines, leading to inhibition of proliferation and induction of apoptosis. Herein, we ...
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