288A Basic Aspects of Thrombosis and Hemostasis 908-159 Pharmacogenetic Warfarin-Dosing Algorithm Is Substantially Improved When Both VKORC1 and CYP2C9 Gene Variants Are Considered cumbersome monitoring. Injectable direct FXa inhibitors offer better safety with efï¬cacy comparable to current treatments. These beneï¬ts could be extended to the ambulatory setting with an oral agent. We evaluate the antithrombotic effects of an oral direct FXa inhibitor DU-176b in a phase I human study. Methods: Healthy males (n=12, 28±6 years) received a single, 60mg dose of DU-176b. Antithrombotic effects were assessed by changes in thrombus size pre- and post-dose, using the Badimon chamber at venous and moderately stenosed arterial ï¬ow conditions. Perfusion studies and measurements for anti-FXa activity and thrombin generation were performed pre-dose, and at 1.5-, 5- and 12-hours post-dose. Results:see table. Effect of DU-176b on Thrombus Formation and Clotting Parameters Anti-Thrombotic Effect Venous Thrombosis (% reduction) Arterial Thrombosis (% reduction) 1.5 hour postdose 28% * 26% * 5 hour postdose 21% * 17% * 12 hour postdose 3% 3% Benjamin D. Horne, Jeffrey L. Anderson, Joseph B. Muhlestein, Robert R. Pearson, Heidi Thomas, Brent C. James, Chrissa P. Mower, John F. Carlquist, LDS Hospital, Salt Lake City, UT, University of Utah,
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Vascular Disease, Hypertension and Prevention
Follow Journal of the American College of Cardiology
, Volume 47 (4)
Elsevier – Feb 21, 2006
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