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Journals Biochemical and Biophysical Research... Volume 307 Issue 2

This study investigated the effect of extracellular annexin I on regulating insulin secretion in MIN6N8a (an insulin secreting cell line) cells. The properties of annexin I receptor in MIN6N8a cells were also determined. Annexin I stimulated insulin release in MIN6N8a cells, regardless of the presence or absence of extracellular Ca 2+ . Confocal microscopy revealed that annexin I bound to the surface of MIN6N8a cells. In addition, FACs analysis showed that annexin I bound to the surface of MIN6N8a cells in a dose-dependent manner. However, the annexin I-stimulated insulin secretion and the annexin I binding were abolished in MIN6N8a cells treated with proteases. Annexin I receptors were regenerated time-dependently. Furthermore, annexin I-stimulated insulin secretion was inhibited by cycloheximide but not by actinomycin D. These results showed that annexin I binds to the surface receptor in order to regulate the stimulation of insulin release in MIN6N8a cells.

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The surface receptor is involved in annexin I-stimulated insulin secretion in MIN6N8a cells

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  • Publisher Elsevier
  • Copyright Copyright © 2003 Elsevier Inc.
  • ISSN 0006-291X
  • D.O.I. 10.1016/S0006-291X(03)01197-5
  • Publisher site Get PDF  

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