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Nuclear Factor -kappa B (NF-κ B ) is an inducible transcription factor that regulates the expression of many genes involved in the immune response. Recently, NF-κ B activity has been shown ...
Nuclear factor -kappa B (NF-κ B ) induces the expression of many pro-inflammatory genes, including cytokines and chemokines. In the past decades, a wealth of clinical as well as animal model-based ...
malignancies involving bone, including solid tumours and multiple myeloma. Following improved understanding of the role of RANK/RANKL in cancer biology , denosumab has already been repurposed as a treatment ...
targets still need to be established. Nuclear receptors (NRs) are a type of transcription factor , which has a key role in several biological processes such as reproduction, development, cellular ...
, and bladder cancer. In addition, DEK appears to participate in multiple cellular processes, including transcriptional repression, mRNA processing, and chromatin remodeling. Sub- nuclear distribution ...
that Pat1b has multiple functions linked to transcription and splicing in nuclear speckles, PML bodies, and nucleolar caps. MB oC | ARTICLE RNA-related nuclear functions of human Pat1b, the P-body mRNA decay ...
extract (lane 4) or whole cell extract (lane 5), and after treatment of nuclear extract with proteinase K (lane 2). B and C, EMSA experiments in the absence (lane 1) or presence of 50-fold excess ...
This study demonstrates a role for nuclear factor of activated T-cell 5 (NFAT5) in the regulation of mTOR signaling in intestinal cells, which suggests that NFAT5 participates in the regulation ...
to the bedside and are expected to extend treatment options in myeloma bone disease and hopefully improve outcome for MM patients. References 1 Ludwig H , Advances in biology and treatment of multiple myeloma ...
analysis, we recognise in RPMI-8402 DMSO-activated cells the intracellular movement of transcription factor NF- B providing its definite intranuclear collocation. Intact cells, purified nuclei and nuclear ...
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