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a mystery. Here we have investigated whether the mitochondrial isoform of phosphoenolpyruvate carboxykinase ( PEPCK - M ) is the GTPase linking hydrolysis of mtGTP made by succinyl-CoA synthetase (SCS-GTP ...
to the cytosolic isoform of PEPCK ( PEPCK -C), although loss of the mitochondrial isoform ( PEPCK - M ) has never been assessed. Despite catalyzing the same reaction, to date the only significant role reported in mammals ...
Phosphoenolpyruvate carboxykinase ( PEPCK ) is a gluconeogenic enzyme with a cytosolic (Pck1/ PEPCK -C) and mitochondrial (Pck2/ PEPCK - M ) isoform . Here we investigate the effect of 3-mercaptopicolinic ...
▪ Abstract Phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) ( PEPCK ) is a key enzyme in the synthesis of glucose in the liver and kidney and of glyceride-glycerol in white adipose tissue ...
Mitochondrial phosphoenolpyruvate carboxykinase ( PEPCK - M ), encoded by the nuclear PCK2 gene, links TCA cycle intermediates and glycolytic pools through the conversion of mitochondrial oxaloacetate ...
Luiz Phillippe R Baptista its subtypes, non-small cell lung cancer (NSCLC) is the most common. Recently, the Vanessa VC Sinatti mitochondrial isoform of the enzyme phosphoenolpyruvate carboxykinase ...
areas. Gluconeogenesis results in the generation of glucose from smaller carbon substrates such as lactate and amino acids. The key gluconeogenic enzyme, phosphoenolpyruvate carboxykinase ( PEPCK ), has ...
, encoding for a cytoplasmic (PCPEK-C or PCK1) and a mitochondrial ( PEPCK - M or PCK2) isoforms , respectively. Increased expressions of both PCK genes are found in cancer of several organs, including colon, lung ...
Phosphoenolpyruvate carboxykinase ( PEPCK ) is known to exist as mitochondrial ( PEPCK ‐ M ) and cytosolic isoforms ( PEPCK ‐C). They are involved in glucose production and play vital roles in regulating ...
of Tg PEPCK mt in the glycolysis-impaired strain was aborted upon induced repression of the mitochondrial isoform , demonstrating its essential role for the glucose-independent survival ...
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