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, the antibody has a disulfide bond connecting the C-terminal Cys214 of the light chain and Cys125 on the CH1-1 loop of the heavy chain , while this inter - chain disulfide bond ( inter -SS bond ) was broken ...
are composed of two conserved heavy and light chains connected by a varying number of disulfide bonds . The heavy chain is composed of three constant domains (CH3, CH2, CH1), and one variable domain (VH) close ...
homogeneity of full-length IgG, and the reducibility of the distant CH1–CL inter - chain disulfide bond . These results confirm the potential of structure-based protein engineering in the context of full-length ...
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