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and by peptide binding [17]. The HtrA2/ Omi activity is shown to be essential for cell survival. Mutation or deletion of HtrA2/ Omi induces ROS ( Reactive Oxygen Species ) generation, and mitochondrial stress ...
. For mitochondrial reactive oxygen species , 2 µM MitoSox™ (Thermo Scientific) in Hanks buffer or MitoSox™ plus 10 µM rotenone was used. Cells were sorted using a MACSQuant® automated flow cytometer (Mitenyi ...
reactive oxygen species (ROS), intracellular reduced glutathione (GSH) level, and cell viability. Modulation of these parameters by a training set of compounds, comprised of established mitochondrial poisons ...
arsenic induces apoptotic process in yeast cells. Reactive oxygen species (ROS) production was observed in the process. Moreover, mitochondrial membrane potential decreased after arsenic treatment ...
. The mitochondrial respiratory chain is both the main site and the target of reactive oxygen species (ROS) production. Consequently, the maintenance of a pool of healthy mitochondria is a crucial challenge ...
induction of mitochondrial chaperones and proteases. In addition, eIF2α is phosphorylated by GCN2, leading to translational attenuation. ROS, reactive oxygen species . Fig. 3 View largeDownload slide ...
that these cell death pathways may be back-up system in case for caspase inactivation, though many of their physiological significance(s) are not yet clear (10,11). Reactive oxygen species (ROS) such as superoxide ...
of sample to the test hole. After 5 min, the relative light unit values were measured with a Luminometer (BioTek, Winooski, USA). Measurement of reactive oxygen species content Reactive oxygen species (ROS ...
Reduction in glutathione followed by a loss in mitochondrial membrane potential and increased production of reactive oxygen species . Inhibition of NFκB/Rel nuclear factor and binds to Bcl-2 to ribosomal S3a ...
are thought to fulfil a critical role in granzyme-A-mediated cell death. However, in contrast to granzyme B, granzyme A induces loss of mitochondrial inner membrane potential and the release of reactive oxygen ...
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