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in molecular biology, cellular biology and genomics, which increased the number of molecular targets and prompted shorter drug discovery timelines. However, emerging trends, coupled with unrealized ...
Summary: Somatostatin drug design by fish-hunting cone snails Somatostatin (SS) is a peptide hormone with diverse physiological roles . By investigating a deep-water clade of fish-hunting cone snails, we ...
to the chemical space. The present review summarizes the role of big data and AI techniques currently being implemented to satisfy the ever-increasing research demands in drug discovery pipelines.Graphic abstract ...
they represent a source, real and potential, of remarkable molecular diversity . Although advances in drug discovery have been significantly fueled and paralleled by advances in synthetic organic chemistry ...
-edge imaging techniques. Emphasizing combat strategies, the review lists potential protein targets within the MPXV lifecycle for computer-aided drug design (CADD). The role of protein–ligand interactions ...
that prevent the formation of these protein complexes could be valuable new therapeutic agents to treat these diseases. Protein interfaces have not evolved to bind low‐ molecular ‐weight molecules, as is the case ...
of the whole cell (16). As demonstrated by Dunstan et al. (17) in this issue of the Journal, cell-based screening assays will continue to play an important role in drug discovery as we move into the molecular ...
for the selection of target fungi. IntroductionNatural products play an important role in the discovery and development of new drugs and agrochemicals (Gunatilaka, ; Newman and Cragg, ), both as sources of directly ...
of viable therapeutic targets and new treatments for CNS disorders and in particular, for NDDs is a major challenge in the field of drug discovery . These difficulties can be attributed to the diversity ...
The Candida genus encompasses a diverse group of ascomycete fungi that have captured the attention of the scientific community, due to both their role in pathogenesis and emerging applications ...
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