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of cannabinoid and anandamide receptors were not modified. Although ineffective in wild-type mice, treatment of ob/ob mice with leptin re-established endocannabinoid levels and enzyme activities back to the values ...
world in the late 19th century, its use has been a source of controversy with respect to its physiological effects as well as the generation of specific behaviors. In this regard, the CB1 receptor ...
pro-TRH mRNA levels despite continuation of fast (8). Leptin’s effect on TRH neurons can be mediated by activating POMC/CART or inhibiting NPY/AgRP neurons, but also directly on TRH PVN neurons (5, 8, 9 ...
, Rissanen AM, Scheen AJ, Ziegler O, Rössner S, RIO-Europe Study Group . Effects of the cannabinoid -1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1 ...
talk between the ECS and leptin on eating behavior and energy homeostasis via central and peripheral mechanisms. Effect of polymorphism of CB receptors on sweet taste and food preferences Genetic ...
World J 7 : 666 – 685 , 2007 . OpenUrl CrossRef 33. ↵ Mark AL , Shaffer RA , Correia MLG , Morgan DA , Sigmund CD , Haynes WG . Contrasting blood pressure effects of obesity in leptin - deficient ob/ob mice ...
engineered cannabinoid -1 receptor (CB1R) deficient mice, which are hypophagic, lean, and resistant to diet-induced obesity (Ravinet Trillou et al., 2004). Therefore, the CB1R has been identified as a potential ...
decreased in amplitude by leptin . The paired-pulse ratio was increased, suggesting leptin effects involved activation of receptors presynaptic to the recorded neuron. A leptin -induced suppression of EPSCs ...
) and the GPR119 (Syed et al., 2012). Cannabinoid receptor signalling. Cannabinoids exert their effects by binding to specific G-protein-coupled receptors . The major pathways and channels activated by CB1 receptor ...
number. Currently, there is no consensus on whether estrogen stimulates or inhibits leptin receptor expression. Additionally, the report that estrogen can induce anorexia in leptin deficient mice suggests ...
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