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The majority of lysosomal enzymes are targeted to the lysosome by post‐translational tagging with N‐glycans terminating in mannose‐6‐phosphate (M6P) residues . Some current enzyme replacement ...
, differing in only four of their 354 amino acids. Changing the residues Arg176→Gly, Gly235→Ser, Leu266→Met and Gly 268→Ala converts the enzyme specificity from blood group A to blood group B ...
an overall 50% identity with its human counterpart14 at the amino -acid level, but fails to bind gp12015. To define those residues of human CD4 critical for gp120 binding, we have taken advantage ...
CD6a, the two C‐ terminal Tyr residues (Tyr 629/662) are critical for the phosphorylation of CD6 following TCR cross‐linking. Isoform CD6e, which is missing a region that contains two proline‐rich motifs ...
(1968). 5, Rauscher, F. Jill, Voulalas, p, J, Franza Jr, B , R. & Curran, T. Genes Dev, 2,1687-1699 (1988), 3a shows that Fos-core 7, a 75- residue peptide which terminates 6. Schuermann, M, et ai, Cell 56 ...
Hepatitis B surface antigen (HBsAg) particles consist predominantly of a glycoprotein of 226 amino acids which bears the B -cell epitopes important for the induction of protective antibody responses ...
fusion. Critically , the successful propagation of VZV in vitro and lesion formation in human skin xenografts in vivo is dependent on the regulation of cell fusion linked to the carboxyl terminal domain ...
Lubowsky, 4 Matthew Avitable, 4~ John Carucci, 5 and Randall B . Murphy 5 Received July 7, 1988 The binding of cancer cells to the basement membrane glycoprotein laminin appears to be a critical step ...
homotrimeric surface antigen glycoprotein on SARS-CoV-2 [19]. Each monomer contains more than 1,200 amino acid residues and is divided into the S1 and S2 subunits (Fig 1A). Based on biological function, S1 ...
monoclonal antibody (mAb) therapeutics and recombinant protein vaccines. HCMV genome encodes many glycoproteins . Seven of these: gB, gH, gL, gO, UL128, UL130 and UL131, are critical for cell entry (reviewed ...
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