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BACKGROUND AND PURPOSE: Decreased glucose metabolism in the temporal and parietal lobes on FDG-PET is recognized as an early imaging marker for the AD pathology . Our objective was to investigate ...
: Decreased glucose metabolism in the temporal and parietal lobes on FDG-PET is recognized as an early imaging marker for the AD pathology . Our objective was to investigate the effects of age on FDG-PET ...
when the two patient groups were compared. A pattern of relatively focused atrophy of the midbrain, hypothalamus and SI, with a relative sparing of the hippocampus and temporoparietal cortex ...
patients. Patients were compared to 37 matched controls. All patients had autopsy (n = 7) or CSF (n = 67) evidence of Alzheimer’s disease pathology . We first assessed atrophy in suspected sites of disease ...
, 28% for preclinical AD , see text and Supplementary Table 2 for details). The ND data for the preclinical AD participants refer to atrophy changes only. (B) Barplots show the molecular pathology status ...
hippocampal atrophy , independently of age, Aβ42, and tau. sTREM2-related atrophy only marginally increased with biomarker positivity across the AD continuum (A−T− #x2292; A+T− #x2292; A+T ...
independently . Most patients with MCI harbor the pathologic changes of AD . The incidence of AD in the cohort with MCI is as high as 10% to 15% per year.6 Global brain atrophy is highly predictive of imminent ...
) showing abnormalities primarily in left temporoparietal regions and posterior cortical atrophy (PCA) showing abnormalities primarily in occipitoparietal regions (Galton et al., 2000; Whitwell et al., 2007a ...
patients for bottom right). AD = Alzheimer’s disease; PiD = Pick’s disease. Figure 4 Open in new tabDownload slide Overlap in grey matter atrophy . Imaging shows the number of patients or pathological ...
. Temporoparietal metabolism, which is characteristically abnormal in AD , was not correlated with cortical atrophy , suggesting that in this sample (with much CVD), cortical atrophy was not simply a consequence of AD ...
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