Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
of death receptor ligation and activate caspase-8 via an activation loop in the C terminus of c-FLIPL. This triggers cleavage of c-FLIPL at Asp-376 by caspase-8 to produce p43FLIP ...
cells in a recombinant herpesvirus saimiri background, potently induces canonical NF -κB signaling through membrane recruitment of the ubiquitin ligase tumor necrosis factor receptor -associated factor 6 ...
- cell receptors (BCRs) on T and B lymphocytes also leads to activation of NF -κB. The engagement of TCRs leads to the immediate activation of a number of protein tyrosine kinases and formation of very ...
triggered NF -κB activation via interacting with membrane receptor TNFR2 on CD4+ T cells . Figure 5. Open in new tabDownload slide Exosomal membrane TNF from CD14+ Mφ triggered NF -κB activation via TNFR2 on CD4 ...
of immature B cells by binding to the EP4 receptor .[ 6 ] Similarly, Ptger4 knockout mice have been shown to develop increased numbers of B cells with greater resistance to spontaneous cell death , since PGE2-EP4 ...
regions in the promoter to up-regulate the expression of IFNs and proinflammatory cytokines, respectively [18,19]. Binding of secreted IFN-a/ b to IFN receptors activates the associated Janus kinases (JAKs ...
in serpinB9 expression compared to unstimulated cells (mean ± SEM, n = 3). ( B ) The inhibitors Bay 11-7082 (Bay, 5 μM) or cycloheximide (CHX, 5 μg/mL) were administered 30 min prior to dsRNA receptor activation ...
, the forced expression of GPR108 is toxic. Transient expression of GPR108 in 293 cells elicits strong NF -κB and IFN-β promoter activation that is attenuated when TLR agonists are applied. Co-immunoprecipitation ...
)-úB signaling pathways are triggered by the cascade of MyD88-Interleukin (IL)-1 receptor -associated kinases-TNF receptor -associated factor 6 (TRAF6), activating a signaling complex containing TGF-à ...
expression of germline γ1 transcripts (35–39,42). However, it still remains unclear whether CD38 ligation of naive B cells activates NF ‐κB. To examine whether CD38 ligation activates NF ‐κB, we stimulated ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!