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, Matsunaga N , Tawada H , et al. TAK-599, a novel N-phosphono type prodrug of anti - MRSA cephalosporin T-91825: synthesis , physicochemical and pharmacological properties , Bioorg Med Chem , 2003 , vol. 11 (pg ...
included headache and gastrointestinal upset. Conclusion Ceftobiprole is a novel , broad-spectrum, parenteral cephalosporin undergoing Phase III clinical trials. Its broad spectrum of activity makes ...
synthesis inhibitor). Ceftobiprole and ceftaroline are novel advanced generation cephalosporins with a broad activity spectrum and strong affinity for PBP2a with ceftobiprole showing stability to β-lactamases ...
) Anti - MRSA cephalosporin (cell wall synthesis inhibitor) No Approved (ABSSSI, CABP) No No No No No No No No Ceftolozane/tazobactam (IV) Antipseudomonal cephalosporin /BLI combination (cell wall synthesis ...
Scholar Crossref Search ADS PubMed WorldCat 9 Ishikawa T Matsunaga N Tawada H et al. . TAK-599, a novel N-phosphono type prodrug of anti - MRSA cephalosporin T-91825: synthesis , physicochemical ...
), an increasing problem in hospitals. Recently, ceftobiprole became the first broad-spectrum cephalosporin with activity against MRSA to be assessed in late-stage clinical trials [23]. Furthermore, another ...
products content [46, 47]. A lot of structurally and pharmacologically important substances have been isolated with novel antimicrobial, antitumor and anti -inflammatory properties [19, 43, 106, 107, 136, 141 ...
derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti ‑tuberculosis activity 1,5 2 2 2,4 2,6 Xinjun Zhang · Hongtao He · Rong Ma · Zengchun Ji · Qi Wei · 2 2,3 2 Huanqin Dai · Lixin Zhang ...
resistant Staphylococci Inhibition of peptidoglycan synthesis [57,58] 9 Bacillus species Mersacidin, a tetracyclic peptide MRSA Bactericidal activity [67] 10 Bacillus amyloliquefaciens Antimicrobial peptides ...
improves activity against MRSA phenotypes.2,5,7 The affinity constant of teicoplanin towards d-Ala–d-Ala precursors is found to be four or five times that of vancomycin.8,9 A semisynthetic version ...
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