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, and functional loss is critical to the development of new therapies. Age and sex have a complex and interactive effect on ischemic stroke risk and pathophysiology. Aging is the strongest nonmodifiable risk factor ...
are synergistic (10). The effects of aging and HFD feeding on expression of Nrf2-driven genes is shown in Figure 4. We found that increased hippocampal oxidative stress in HFD-fed aged mice is not associated ...
al. Liver-specific knockdown of IGF-1 decreases vascular oxidative stress resistance by impairing the Nrf2-dependent antioxidant response: a novel model of vascular aging . J Gerontol A Biol Sci Med ...
confounding variables. Human growth hormone is both antigenic and prolactinogenic which can potentially limit anabolic effects and introduce non-specific actions of the hormone. For rodent models , these two ...
, did not extend life span in nonobese rodents but appear nonetheless to have pleotropic effects on age -related diseases and physiological function. Many novel agents are under development to target ...
to promoting weight loss, though adherents tend to gain less weight over time (9). In basic aging research, rodent models of caloric restriction have long been known to promote longevity. However, specific ...
areas, implying their potential use as vehicles for therapeutic agents administration. Indeed, various advantageous effects were reported following human MSCs transplantation into rodent models ...
. Recently, estrogen has been shown to mediate this stress response (123), suggesting that protein destabilization may mediate the effects of estrogen blockade on accelerated aging . Deleterious Effects ...
Abstract Obesity has deleterious effects on cognitive function in the elderly adults. In mice, aging exacerbates obesity-induced oxidative stress , microvascular dysfunction, blood–brain barrier (BBB ...
model of neonatal hypoxic-ischaemic brain injury, we investigated the potential neuroprotective effect of exendin-4 in both postnatal Day 7 and 10 mice. An optimal exendin-4 treatment dosing regimen ...
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