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In this study, hydrophilic PLGA/Pluronic F127 scaffolds loaded with a pDNA/PEI‐PEG complex were prepared to estimate their potential use as a polymeric matrix for pDNA delivery . The scaffold ...
delivery of bioactive factors, such as protein growth factors and DNA , to alter cell function in localized regions. Factors can be released from highly porous polymer scaffolds to allow factor delivery ...
Background To overcome the extracellular barriers in gene delivery and direct gene delivery to target tissues , substrate‐mediated transfection, which sustains the release of naked DNA or vector/ DNA ...
and osteogenic lineages. © 2004 Wiley Periodicals, Inc. J Biomed Mater Res 71A: 586–595, 2004 INTRODUCTION In the emerging field of tissue engineering, biodegradable polymeric scaffolds are used as templates ...
the human BMP-2 coding region (pBMP-2) to transfect MSCs. The alginate hydrogel functions both as a delivery vehicle for plasmid DNA to cells [28, 29], and as temporary matrix for seeded cells [30, 31 ...
from porous scaffolds . J. Control. Release 86 : 157 – 168 . Google Scholar Crossref Search ADS PubMed WorldCat Jang , J. H. , Rives , C. B., Shea , L. D. ( 2005 ) Plasmid delivery in vivo from porous ...
. , Peters , M. C., Kohn , D. H., Mooney , D. J. ( 2000b ) Sustained release of vascular endothelial growth factor from mineralized poly(lactide-co-glycolide) scaffolds for tissue engineering . Biomaterials 21 ...
of this minicircle-nanoparticle solution was applied to the base of each HA-PLGA scaffold , such that each scaffold contained 10,000 ng of plasmid DNA . To visualize the construct, scanning electron microscopy ...
systems for ocular gene therapy Delivery system . Nucleic acid (target) . Target disease/cell line/ tissue . Ref. . (A) Polymeric particles PLGA microspheres PS-AsODN (TGFβ2) (with PEI) Bleb survival after ...
scaffolds or hydrogels and lipid-based gene delivery reagents were developed to allow direct in situ transfection of cells that grow in 3D matrices (18,19). While this system maintains a permanent ...
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