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, is illustrated by the antiviral activity of amantadine , which targets the ion-channel forming protein M2 and prevents Influenza A infections [28]. Given the recent scenario of frequent outbreaks of Chikungunya ...
antiviral influenza drugs have two major classes based on M2 ion channel inhibitors ( amantadine and rimantadine) and NA inhibitors (oseltamivir, zanamivir, and peramivir) [6]. However, many drug-resistant ...
maturation. The first anti- influenza virus drug, amantadine , is a specific blocker of the M2 H+ channel. Amantadin and its derivative have been widely abandoned due to virus resistance. HA binds to sialic acid ...
nonlinear. Neutron-scattering curves showed only subtle changes in wall structure , including a slight increase in cellulose microfibril alignment along the growing stem. In contrast, solid-state nuclear ...
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