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bioengineering using expanded human corneal endothelial cells (hCECs) appears to be a particularly feasible and viable technique in the short term for supplying extra tissue for endothelial keratoplasty (EK)[4,5 ...
for the culture of HCECs [34]. Human Corneal Endothelial Cell Markers Structural markers such as ZO-1, which is a tight junctional protein, have been used widely to study the junctions of in vitro expanded HCECs ...
. These new findings point to the need for the transplantation of new healthy cells in human chronic wounds. Bioengineered living skin constructs can deliver new cells to chronic wounds, at least for a limited ...
a three-dimensional (3D) view of the entire human corneal limbus and identify the structural characteristics of the LESC niche. Two distinct candidate LESC niche structures were identified. Cells within ...
CEC from human ESC/iPSC-derived NCSC in an in vitro two-step process. This approach offers promise for the development of endothelial replacements suitable to treat corneal edema due to pathological CEC ...
] Human In vitro Yes No Poor evidence without control data Inc. Ep Umbilical cord blood [41] Human Organ culture Human Yes Yes Yes (GFP) A shift observed toward a phenotype similar to corneal endothelial ...
introduction of CSSCs into the corneal stroma generated transparent tissue in a mouse model of corneal opacity. Human CSSCs injected into mice corneas did not elicit immune rejection over an extended period ...
the basal lamina. Small and round [14-17] Keratocytes CD34, CD133, l-selectin, keratocan, ALDH Fibroblastic, myofibroblastic, adipogenic, osteogenic, chondrogenic, corneal epithelial, corneal endothelial ...
individuals. In this study, stem cells isolated from adult human corneal stroma were examined for the ability to correct stromal opacity in a murine model by direct injection of cells into the corneal stroma ...
become fibroblastic, secreting nontransparent tissue. This study sought to identify progenitor cells for human keratocytes. Near the corneal limbus, stromal cells expressed ABCG2, a protein present in many ...
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