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In this issue, Levy and Levy (1) report on the development of an ELISA using single - chain antibodies (ScAbs) from a phage library for the determination of the major haptoglobin (Hp) phenotype ...
Abstract Computer-guided library generation is a plausible strategy to optimize antibodies . Herein, we report the improvement of the affinity of a single -domain camelid antibody for its antigen using ...
the demands for molecular biological analysis in vitro . However, for therapeutic application, the vectors from which the antibody fragments are expressed must be delivered to the appropriate cells. ‘Transbody ...
and transcriptional dysregulation. Altering the protein context of the polyQ had the potential to alter the misfolding kinetics; therefore, an intrabody approach seemed justified. Using the Sheets single - chain Fv (scFv ...
) and the RSCB Protein Data Bank (Berman et al., 2000). The Fv moieties from the crystal structures of the Fab fragments KOL (human; λ light chain ; PDB code 2FB4), HC19 (murine; λ light chain ; PDB code 1GIG ...
TIFF original image Table 3. Panel of 20 single -mutation variants selected for affinity maturation of the anti-muCCL20 monoclonal antibody . Mutations 2, 10, 14 and 16 were selected from Discovery Studio ...
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