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. Finally, we studied the influence of cilnidipine and other calcium‐channel blockers on stimulation‐induced chronotropic responses, in order to address N ‐ or L ‐ type selectivity , in the pithed rat model (male ...
of Science 29. ↵ Uneyama H , Uchida H , Konda T , Yoshimoto R , Akaike N . Selectivity of dihydropyridines for cardiac L - type and sympathetic N - type Ca2+ channels . Eur J Pharmacol 373 : 93 – 100 , 1999 ...
. Angelico P , Guarneri L , Leonardi A, Testa R: Vascular- selective effect of lercanidipine and other 1,4- dihydropyridines in isolated rabbit tissues . J Pharm Pharmacol 1999 ; 51 : 709 – 714 . Google Scholar ...
, Dascal N , Flockerzi V , Hofmann F . Tissue-specific expression of high-voltage-activated dihydropyridine -sensitive L - type calcium channels . Eur J Biochem 200 : 81 – 88 , 1991 . OpenUrl Medline Web ...
Abstract Stress elevates blood pressure (BP) by increased sympathetic nerve activity. Cilnidipine, a novel dihydropyridine calcium antagonist that has inhibitory actions on N - type as well as L - type ...
and Little, 2002). Further, long-term alcohol exposure in rats has been reported to increase the number of dihydropyridine binding sites of cardiac l - type Ca2+ channels (Guppy et al., 1995) and enhance ...
-channel blocker of usual choice in the management of cardiac arrhythmias. L - type calcium-channel blockers are categorised into three distinct groups based on structure: phenylalkylamines (e.g. verapamil ...
current, or tiny conductance), and N (non- L , non-T- type ) [80], with L - type and T- type found in heart. The L - type was further characterized by its interaction with dihydropyridines . Although both types ...
Abstract / FREE Full Text 25. ↵ Hansen PB , Poulsen CB , Walter S , Marcussen N , Cribbs LL , Skott O , Jensen BL . Functional importance of L - and P/Q- type voltage-gated calcium channels in human renal ...
of this type , in particular the non-retarded nifedipine preparation provoke sympathetic activation and reflex tachycardia. Conversely, the more recently introduced dihydropyridines with a slow and long action ...
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