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Journals Biotechnology Advances Volume 16 Issue 4

Biotechnology Advances, Vol. 16. No. 4. pp. 781-898. 1998 Copyright Q 1998 Elsevier Science Inc. F’riited in the USA. All rights reserved 0734-9750/98 $19.00 + .oO PII s0734-9750(98)oooo8-1 Mutation/Genetic Engineering Techniques 35716 TEMPERATURE CONTROL APPARATUS AND METHOD Stapleton Marilyn J; Jewett Warren Durham, NC, UNITED STATES assigned to Gene Tee Corporation An apparatus and method for performing automated sample DNA preparation, amplification and detection, which apparatus has heat-sinking, Bat carriers for holding specimens and reagents,devices for heating and cooling and maintaining the specimen to or at any given temperature for any given time periods, and a computer to generate signals that control said temperatures and times. This invention provides an apparatus and method for analyzing a polynucleotide sequence;either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array the whole or a chosen part a complete set oligonucleotides which are capable taking part in hybridization reactions. The array may comprise one or more pair oligonucleotides chosen lengths. The polynucleotide sequence, or fragments there, are labelled and applied to the array under hybridizing conditions. Applications include analyses known point mutations, genomic fingerprinting, linkage analysis, characterixation mRNAs, mRNA populations, and sequence determination. 5700639 METHOD

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Section B. Classified patent abstract

Biotechnology Advances , Volume 16 (4)
Elsevier – Jul 1, 1998

More Info
  • Publisher Elsevier
  • Copyright Copyright © 1998 Elsevier Ltd
  • ISSN 0734-9750
  • D.O.I. 10.1016/S0734-9750(98)00008-1
  • Publisher site Get PDF  

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