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Search ADS PubMed 5. Funakoshi T , Latif A , Galsky MD . Safety and efficacy of addition of VEGFR and EGFR - family oral small -molecule tyrosine kinase inhibitors to cytotoxic chemotherapy in solid cancers ...
patients is under way [96]. AEE788 is an orally active, reversible, small -molecule, dual- family inhibitor against EGFR , HER-2, and VEGFR -2 with antitumor and antiangiogenic activity [97, 98]. To date ...
schedule, the optimal setting of evaluation, and the safety of long-term use of vandetanib. Vandetanib, VEGFR , EGFR , RET, Clinical trials Introduction Vandetanib (ZD6474) (N-(4-bromo-2-fluorophenyl)-6 ...
of efficacy , possibly because of the development of resistance [72, 79]. In addition , there is continuing debate over the efficacy and safety profiles of platinum- versus nonplatinum-based chemotherapy regimens ...
(20, 30, and 45 mg) with the EGFR tyrosine kinase inhibitor gefitinib (250 or 500 mg) [80]. AEE788 is a novel, synthesized, oral small -molecule inhibitor of both EGFR and VEGFR tyrosine kinases [81 ...
include vatalanib (PTK787/ZK-222584), SU11248, and ZD6474. Vatalanib is an orally available small -molecule TKI that is a potent inhibitor of VEGFR -1 and VEGFR -2 [16]. SU11248 inhibits VEGFR -2 and PDGF [17 ...
angiogenesis (through inhibition of VEGFR and PDGFR signaling). Sunitinib (SU11248) is a novel small molecule, an orally selective multitargeted RTK inhibitor that exhibits direct antitumor activity against ...
; TKI, tyrosine kinase inhibitor; VEGFR , vascular endothelial growth factor receptor. Open in new tab Table 3 EGFR family targeted agents in phase II/III clinical development for NSCLC aNo phase III ...
drug has been synergistic in preclinical models [22–25]. Second-generation EGFR TKIs have been developed that, in addition to blocking EGFR signaling, target additional members of the ErbB family ...
. Safety and efficacy of addition of VEGFR and EGFR - family oral small -molecule tyrosine kinase inhibitors to cytotoxic chemotherapy in solid cancers: a systematic review and meta-analysis of rand- omized ...
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