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regulation of one or more cellular RNAs bound by TDP - 43 causes disease (15). Experiments carried out to study the function of TDP - 43 have revealed its direct physical RNA targets in specific cell types ...
was performed as described (12). The biotin-labeled DNA probes used were listed in Supplementary Table S2. UV - CLIP DAP- TDP - 43 -expressed T-REx 293 cells were cultured in a 150-mm Petri dish, exposed to UV light ...
. Briese M. Cereda M. Kayikci M. Konig J. Hortobagyi T. Nishimura A.L. Zupunski V. et al . . ( 2011 ) Characterizing the RNA targets and position-dependent splicing regulation by TDP - 43 . Nat. Neurosci ., 14 ...
xenobiotics, evaluate current methods for identifying aberrant lncRNA expression and molecular target interactions, and discuss the potential to implement these tools to address fundamental questions ...
validation of selective differential expressed genes (DEGs) identified by RNA -Seq. (B) Schematic of performing UV cross-link coupled with FUS immunoprecipitation ( CLIP ) followed by RT-PCR using LN229 ...
al . (42) have identified 6 potential tRNA targets of previously uncharacterized Caenorhabditis elegans snoRNAs in a bioinformatic screening campaign. The snoRNAs presumably target nucleotides ...
). Importantly, expression of human FTSJ1 in yeast suppressed the severe growth defects observed in trm7Δ mutants, demonstrating that the TRM7 enzyme family and their RNA targets are highly conserved (45). While ...
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