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Introduction: Benzodiazepines (BZDs) are used in the management of anxiety and sleep disorders; however, chronic use is associated with tolerance and dependence. During withdrawal, symptoms ...
with newly diagnosed epilepsy, ELB 138 markedly reduced seizure frequency and severity without significant difference to standard treatments (phenobarbital or primidone) but was much better tolerated than ...
-GABAAcomplex could indicate an a priori differential expression of GABAA- benzodiazepine receptors in patients with panic disorder. For instance, increased expression of α6subunits, to which [11C] flumazenil does ...
of GABAAreceptors to ethanol is reduced by protein kinase C inhibition.Also, protein kinase Cγ-null mice show reduced ethanol but not benzodiazepine sensitivity of GABAAreceptors and increased ethanol preference ...
precipitate symptoms of benzodiazepine withdrawal, including seizures.77–80 Additionally, in cases of multiple-drug ingestion, flumazenil may remove the protective effect of the benzodiazepine and unmask ...
, midazolam, haloperidol, naloxone, flumazenil , and glucagon. The available data do indicate, however, that intranasal administration may be a safe, effective, and well tolerated route of administration ...
results in benzodiazepine tolerance . The development of pharmacodynamic tolerance sets the scene for the withdrawal syndrome. Cessation of the drug exposes all the adaptations which have accrued ...
depression. Patients with renal or hepatic dysfunction may have a prolonged recovery from PSA due to reduced drug metabolism and elimination. Highly opioid- tolerant patients, such as those with a history ...
by an increase of γ2 subunit expression in many nuclei. In the entorhinal cortex, the expression of all GABAA receptor subunits was decreased except for the α1 subunit, which was increased on cellular somata ...
. However, mitotane treatment did have some physiological effects, as it reduced the resting heart rate and the duration of the heart rate response to a sudden noise. It also prevented the increase ...
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