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kidney with lower affinity for ET‐ 1 that is coupled to a vasoconstrictor mechanism . ETA receptor - mediated responses to endothelin - and big endothelin - in the rat kidney 'David M. Pollock & Terry J ...
that the level of circulating ET- 1 is regulated by ETA receptor - mediated negative feedback. This mechanism seems to be coupled to increased conversion of big ET- 1 and is most potent in the kidneys. This emphasizes ...
- and non- receptor - mediated clearance of big - endothelin and endothelin - 1 : differential effects of acute and chronic ET receptor blockade a b a Mick Burkhardt , Matthias Barton and Sidney G. Shaw Aims ...
- receptor antagonists (22); the mechanism for this may be either displacement of ET- 1 from ET receptors by the receptor blockers, or up-regulation of ET- 1 production. An assay for big ET- 1 may further ...
Immunocytochemical localization of big endothelin ‐ 1 ( big ET‐ 1 ), ET‐ 1 , and ET receptor A and B (ETA and ETB), and gene expression of prepro ET‐ 1 mRNA were examined on the rat liver vasculature ...
, David J. Webb, Thomas Sandstro¨m, Anders Blomberg, David E. Newby Abstract—Diesel exhaust inhalation impairs vascular function, and, although the underlying mechanism remains unclear, endothelin (ET) 1 ...
proliferation probably through endothelin ETA or ETA‐like receptors . The underlining mechanism of cell growth by ET‐ 1 ( 1 ‐31) may be explained in part by PKC‐dependent ERK1/2 activation. Since human chymase has ...
receptors . ECE, endothelin converting enzyme; NEP, neutral endopeptidase. Fig. 1 . View largeDownload slide Proteolytic processing of preproendothelin‐ 1 and big endothelin ‐ 1 (=proendothelin‐ 1 ) in biosynthesis ...
Abstract Background The peptide endothelin (ET) 1 promotes proliferation in a number of epithelial cancers. The aim of this study was to identify the mechanism of ET- 1 -stimulated proliferation ...
during a HS diet is mediated by increased vasodilatory function of endothelial ET B receptors . By preserving renal blood flow, this may be an important mechanism to restore sodium balance during a HS diet ...
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