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The cell cycle is a complex process that involves DNA replication, protein expression, and cell division. Dysregulation of the cell cycle is associated with various diseases. Cyclin-dependent kinases ...
drugs are structurally more complex than small molecules , and yet share a similar principle for rational drug discovery and development: That is to start with a pre-defined target and follow ...
Development of new products often relies on the discovery of novel molecules . While conventional molecular design involves using human expertise to propose, synthesize, and test new molecules ...
There are two main ways to discover or design small drug molecules . The first involves fine-tuning existing molecules or commercially successful drugs through quantitative structure-activity ...
greater automation into the small - molecule drug discovery process. Schneider highlights approaches and technologies that seem poised to be implemented robustly by medicinal chemists in the near future ...
of human genomic variation with circulating small molecule data obtained across different measurement platforms enables efficient discovery of genetic regulators of human metabolism and translation ...
in fields such as functional genomics and therapeutics. siRNA ( small interfering RNA), a 21–25 nucleotide, double‐stranded RNA molecule plays a major role in gene silencing. The RNAi machinery involves ...
of QSAR applications that we term ‘deep QSAR’. Marking a decade from the pioneering applications of deep QSAR to tasks involved in small - molecule drug discovery , we herein describe key advances in the field ...
review key concepts and specific features of small - molecule –protein docking methods, highlight selected applications and discuss recent advances that aim to address the acknowledged limitations ...
of biological molecules to cover short and long distances. However, a recent discovery in this communication network is the involvement of extracellular vesicles that host biological contents such as proteins ...
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