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to major BrC susceptibility genes including BRCA1 and BRCA2, other high- (such as TP53 and PTEN) and moderate- (CHEK2, ATM, BRIP1, PALB2, and RAD51C ) penetrance susceptibility genes were found to play role ...
cancers. As such, several genes such as PALB2 are reclassified as cancer predisposition genes . But evidence for cancer risks remains unclear for many others. In this review, we will discuss cancer ...
common feature of FA is the progressive development of hematopoietic stem cell failure and a predisposition to particular types of cancer, such as myelodysplasia/leukaemia, head and neck squamous cell ...
by pancytopenia, bone marrow failure, developmental defects and increased incidence of cancer, particularly acute myeloid leukaemia and squamous cell carcinoma of the head and neck . FA is phenotypically ...
revealed a novel signature for reactive HD astrocytes, including a downregulation of NOTCH signaling and fatty acid synthesis genes , and an upregulation of MHC class I and metallothionein genes . Our findings ...
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