Background Traditional materials used as in vitro cell culture substrates are rigid and flat surfaces that lack the exquisite nano- and micro-scale features of the in vivo extracellular environment. While these surfaces can be coated with harvested extracellular matrix (ECM) proteins to partially recapitulate the bio-instructive nature of the ECM, these harvested proteins often exhibit large batch-to-batch variability and can be difficult to customize for specific biological studies. In contrast, recombinant protein technology can be utilized to synthesize families of 3 dimensional protein-engineered biomaterials that are cyto-compatible, reproducible, and fully customizable.
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Protein-engineered biomaterials: Nanoscale mimics of the extracellular matrix
Romano, Nicole H.; Sengupta, Debanti; Chung, Cindy; Heilshorn, Sarah C.
Follow Biochimica et Biophysica Acta (BBA) - General Subjects
, Volume 1810 (3)
Elsevier – Mar 1, 2011
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