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and an inability to protect against topical treatment with high doses of TPM. Low circulating levels of curcumins have been reported after dietary exposure of rats to turmeric (Ravindranath and Chandrasekhara, 1980 ...
the underlying mechanisms of in vitro genotoxicity effects. Efficiently discriminating between real genotoxicants and chemicals which induce false or misleading in vitro positives is required to allow a better ...
, M. , Sasi , P., Gupta , V. H., Rai , G., Amarapurkar , D. N. and Wangikar , P. P. ( 2012 ) Protective effect of curcumin , silymarin and N-acetylcysteine on antitubercular drug- induced hepatotoxicity ...
by genotoxic compounds. Therefore, carotenoids and vitamin A appear to work via multiple mechanisms, which would support a potential protective role in cancer initiation and in the pathogenesis of other mutation ...
herbs are commonly used. AA-DNA adducts combined with the unique mutational spectrum induced by AA in cancer driver genes, provide compelling evidence for a role of AA in upper urothelial tract cancer. We ...
on background and historical control levels. Monday, Plenary Lecture: 0905 The genetic basis of how mammals protect against genotoxic metabolites Ketan Patel MRC Laboratory for Molecular Biology, Cambridge, UK ...
and/or nicotine (natural insecticide) present in tobacco leaves, which has potential to induce DNA damage (4–6). Effects of mixtures of pesticides can be more genotoxic and cause more risks to exposed populations ...
Abstract The comet assay (alkaline single-cell gel electrophoresis, SCG or SCGE) is frequently used in biomonitoring to detect genotoxic effects in humans exposed at the workplace ...
. 38, 637 –646. St Clair, D. K., Jordan, J. A., Wan, X. S., and Gairola, C. G. ( 1994 ). Protective role of manganese superoxide dismutase against cigarette smoke- induced cytotoxicity. J. Toxicol ...
Arecoline is a parasympathomimetic tertiary amine which acts on both nicotinic and muscarinic receptors and therefore has been used against the symptoms of schizophrenia.7 It has been reported to be genotoxic ...
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