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Journals Progress in Neurobiology Volume 95 Issue 3

Highlights ► Sirtuins are NAD + -dependent histone deacetylases. ► SIRT1 is the best characterized sirtuin expressed in neurons. ► SIRT1 is protective against acute and chronic neurological diseases. ► Deacetylation on histone and non-histone targets contributes to the protective effects of SIRT1. ► The activity of SIRT1 is adjustable, making it a neuroprotective target.

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Protective effects and mechanisms of sirtuins in the nervous system

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  • Publisher Elsevier
  • Copyright Copyright © 2011 Elsevier Ltd
  • ISSN 0301-0082
  • D.O.I. 10.1016/j.pneurobio.2011.09.001
  • Publisher site Get PDF  

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