Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
following lung gene delivery in clinical trials of gene therapy * Trial . Vector used . Disease . Major immunological findings . Reference . Zabner et al. 1996 Adenovirus Cystic fibrosis Repeated, five ...
Search ADS PubMed WorldCat 6 Jiang , Q. and Engelhardt , J.F. ( 1998 ) Cellular heterogeneity of CFTR expression and function in the lung : implications for gene therapy of cystic fibrosis . Eur. J. Hum ...
adenovector‐ mediated gene expression and may be useful for clinical applications of current adenovirus ‐ mediated gene therapy . Copyright © 2003 John Wiley & Sons, Ltd. IntroductionLung and breast cancers ...
. Introduction The lung is a target for gene therapy to treat disease, most notably cystic fibrosis (CF). CF lung disease is characterized by persistent, progressive inflammation and infection, eventually leading ...
) Cationic lipid- mediated CFTR gene transfer to the lungs and noses of patients with cystic fibrosis : a double-blinded placebo-controlled study . Lancet 353 : 947 – 954 . Google Scholar Crossref Search ADS ...
Abstract Phase one clinical trials for gene therapy of cystic fibrosis are in progress using either liposomes or adenoviral vectors for CFTR gene transfer to epithelial cells in the airways ...
review of the manuscript. FUNDING National Institutes of Health [NIH P01 HL-51670, NIH P01 HL-091842, NIH R01 HL-133089, NIH R01 HL-105821]; Center for Gene Therapy of Cystic Fibrosis [NIH P30 DK-054759 ...
the current biological strategies employed in clinical trials utilizing adenoviral mediated gene therapy for cancer. Understand modifications that may improve the utility of adenoviral vectors for gene therapy ...
. Identification of susceptibility genes for development of venous thrombosis should make it possible to develop therapies to prevent pulmonary embolism. While lung transplantation is useful for progressive ...
- mediated - gene transfer [127]. It is likely that recombinant AAV vectors will be employed for the treatment of cystic fibrosis [128] instead of adenoviruses. Cationic Liposomes and Other Nonviral Vector ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!