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Introduction The conformational conversion of the host-encoded prion protein (PrP) is a central pathogenic event in the prion diseases [1]. In healthy individuals, PrP adopts a fold that is rich in α ...
observation of the kinetics of the prion induced misfolding and aggregation of the recombinant substrate. Since its first introduction, RT-QuIC has been applied to human prion disease diagnosis [14–16 ...
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