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The neuronal glutamate transporter , excitatory amino acid carrier 1 ( EAAC1 ), has a diverse array of physiologic and metabolic functions. There is evidence that there is a relatively large ...
The excitatory amino acid carrier 1 ( EAAC1 ) is a sodium-dependent glutamate transporter widely found in the mammalian brain and mainly localized in the somatodendritic compartment of neurons ...
Abstract : EAAC1 ‐mediated glutamate transport concentrates glutamate across plasma membranes of brain neurons and epithelia. In brain, EAAC1 provides a presynaptic uptake mechanism to terminate ...
accumulate in urine. In the central nervous system (CNS), EAAC1 is expressed in the perisynaptic membrane of glutamatergic neurons (6) , and uptake via EAAC1 prevents glutamate spillover and the subsequent ...
EAAC1 /EAAT3 is a transporter of glutamate (Glu) present at the post‐synaptic neuronal element, in opposition to the two other main transporters , GLAST/EAAT1 and GLT1/EAAT2, expressed ...
from the cytosol to the plasma membrane . Contextual fear conditioning increased the maximum rate (V max) of glutamate uptake and membrane expression of EAAC1 in area CA1. These results indicate ...
GLUTAMATE transport across plasma membranes of neurons , glial cells and epithelial cells of the small intestine and kidney proceeds by high- and low-affinity transport systems1–5. High-affinity (Km 2 ...
Astrocytes clear synaptically released glutamate from the extracellular space through high‐affinity transporters present on their plasma membrane . By controlling the extracellular level of the main ...
is not a sufficient stimulus for alteration of plasma membrane expression of EAAC1 . Instead, only when the protein kinase C pathway was activated, would increased intracellular L- glutamate result in decreased EAAC1 ...
trafficking to or from the plasma membrane . Our recent studies suggest that one of the classical subtypes of PKC, PKCα, may selectively mediate redistribution of the neuronal glutamate transporter , excitatory ...
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