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and gastroesophageal reflux disease, respectively. 1 The histamine H 3 receptor ( H 3 R), pharmacologically characterized in 1983 3 and cloned in 1999, 4 is mainly found in the central nervous system where it plays ...
, was identified as a novel histamine H3 receptor agonist. ZEL-H16 was found to bind to human H3R with a Ki value of approximately 2.07 nM and 4.36 nM to rat H3R. Further characterization indicated that ZEL-H16 ...
kinase MeHA methylhistamine Introduction The H 3 receptor ( H 3 R) was detected in the 1980s as an autoreceptor controlling histamine synthesis and release in the rat and human brain ( ; ; ). The cDNAs ...
MH ( R )‐ α ‐methyl‐ histamine S α MH ( S )‐ α ‐methylhistamine Introduction To date, a majority of histamine H 3 receptor ‐binding studies have relied on the H 3 receptor ‐selective agonists [ 3 H ]R α MH ...
, both agonists can serve as useful pharmacological tools in studies of histamine H4 receptors . Abbreviations: CRE cAMP responsive element JNJ 7777120 1‐[(5‐chloro‐1 H ‐indol‐2‐yl)carbonyl]‐4 ...
of Pharmacology (2000) 131, 1247–1250; doi:10.1038/sj.bjp.0703712 Abbreviations: H 3 R histamine H 3 receptor hH 3 R human histamine H 3 receptor rH 3 R rat histamine H 3 receptor TM transmembrane domain ...
The histamine H 4 receptor is the most recently identified member of the G‐protein coupled histamine receptor family, displaying distinct molecular and pharmacological properties from H 1 , H 2 and H 3 histamine ...
characterization of the monkey histamine H receptor B. B. Yao, R. Sharma, S. Cassar, R. Faghih, Y. Bennani, T. A. Esbenshade and A. A. Hancock Neuroscience Research, Global Pharmaceutical Research and Development ...
coupled to the adenylate cyclase in CHO cells, but does not influence the inositolphosphate turnover or arachidonic acid release. Pharmacological characterization of the human histamine H2 receptor stably ...
rat histamine H 3 receptor hH 3 R human histamine H 3 receptor Introduction The histamine H 3 receptor ( H 3 R) was initially characterized as an autoreceptor regulating histamine release in brain ...
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