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, respectively. Analysis of methylation and gene expression patterns of DLX3 in 64 specimens of B -lineage ALL revealed that DLX3 presents aberrant methylation in paediatric B -ALL patients. In vitro experiments ...
methylated in NPC tumors was isolated and showed high homology to the 5′ CpG island of the endothelin receptor B (EDNRB) gene . Since the EDNRB gene is commonly inactivated in prostate and bladder cancers ...
methylation analysis simultaneously assessing 249 CpG dinucleotides originating from 57 genes was employed. Hereby, samples from precursor B - cell acute lymphoblastic leukemia (ALL) could be distinguished from ...
methylated regions flanking the promoter of CXCL12 by cloning bisulfite treated DNA containing the distinct CpG regions and also correlate methylation pattern with the gene expression in different breast tumor ...
methylation patterns ( 17 , 18 ). The aspects of epigenetic gene silencing are therefore myriad, but in this review I shall focus on promoter CpG island hypermethylation, clarifying some of the unsolved issues ...
, which often show aberrant promoter CpG island hypermethylation and transcriptional silencing of tumor suppressor genes and pro-differentiation factors 3,4,5 . We find that for such genes , both normal ...
revealed that CRY1 expression in LR CLL cells is silenced by aberrant promoter CpG island hypermethylation. The methylation pattern of the CRY1 promoter proved to have high prognostic impact in CLL where ...
or unmethylation in cancer (5–8). In fact, the methylation status of the promoter CpG island among MGMT non-expressed cancer cells varies from hypermethylation to hypomethylation (9). The silencing mechanism ...
repression, the distribution of methyl ‐ CpGs in the CpG island differed markedly. In a cell line with gene silencing , the promoter region was almost methylation ‐free. Chromatin immunoprecipitation analysis ...
of genes and presumably takes place when a breakdown occurs in the mechanisms that normally protect CpG islands from the DNA-methyltransferase enzymes. Genes that are silenced by inappropriate promoter ...
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