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) versus cyclooxygenase - 2 selective NSAIDs. The role of co-therapy with proton pump inhibitors in enhancing gastrointestinal safety is also reviewed. In a recently published article in BMC Medicine ...
cyclooxygenase ‐1 (COX‐1) is mainly involved in the management of homeostatic functions, cyclooxygenase ‐ 2 (COX‐ 2 ) is induced in response to inflammation ( Pairet & Engelhardt, 1996 ; Clark, 2006 ; Drag , 2007 ...
Nonsteroidal antiinflammatory drugs (NSAIDs), including selective cyclooxygenase (COX)- 2 inhibitors, have come to play an important role in the pharmacologic management of arthritis and pain ...
Non-steroidal anti-inflammatory drugs (NSAIDs) and selective cyclooxygenase (COX)- 2 inhibitors are commonly used to control pain and inflammation in osteoarthritis . However, these agents have been ...
To the Editor: In his Clinical Crossroads article about a 57-year-old man with arthritis, Dr Lonner1 stated that cyclooxygenase - 2 (COX- 2 ) selective inhibitors are as effective as nonselective ...
nephritis, and papillary necrosis can be serious. The cyclooxygenase - 2 (COX- 2 )- selective NSAIDs (celecoxib, rofecoxib) have been associated with a reduced frequency of gastrointestinal adverse events ...
pain treatment strategies. REVIEW The role of tramadol in current treatment strategies for musculoskeletal pain Stephan A Schug Abstract: Non- selective and cyclooxygenase - 2 (COX- 2 ) selective non ...
BackgroundThe differential effects of selective cyclooxygenase - 2 (COX- 2 ) inhibitors compared with nonspecific nonsteroidal anti-inflammatory agents (NSAIDs) on platelet aggregation and prostacyclin ...
Abstract Objectives Non-steroidal anti-inflammatory drugs play a major role in the management of osteoarthritis (OA). However, it remains unknown whether these drugs affect cartilage and synovial ...
,and the roles of COX-1 and COX- 2 in the pathogenesis of these symptoms are unclear.Rofecoxib (VIOXX) selectively inhibits COX- 2 ; at doses of up to 375 mg/d for 12 daysand up to 1000 mg in single doses,it had ...
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