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Abstract RecJ reportedly participates in the base excision repair (BER) pathway, but structural and functional data are scarce. Herein, the Deinococcus radiodurans RecJ (drRecJ) deletion strain ...
) epigenetic and transcriptional regulation of genes involved in genotoxic responses and (iii) paracrine effects of secreted DNA repair enzymes triggering the cell senescence phenotype. The base excision repair ...
excision repair (NER) (16), transcription-coupled nucleotide excision repair (TCNER) (17), base excision repair (BER) (18) and mismatch repair (MMR) (19,20). During NER, DNA damage recognition requires ...
Abstract Subunit 2 of DNA damage-binding protein complex (DDB2) is an early sensor of nucleotide excision repair (NER) pathway for eliminating DNA damage induced by UV radiation (UVR) and cisplatin ...
XPF-ERCC1 is a key enzyme involved in several of these DNA repair pathways. It is a key component of both branches of nucleotide excision repair (NER), where it removes bulky DNA lesions such as those ...
excision repair , which identify damaged bases , excise them, and perfectly patch the DNA. However, there is a much higher-level orchestrator of the cellular response to damaged DNA that deals ...
in multiple cellular systems and pathways, including DNA base excision repair , interstrand cross-link repair , transcription, chromatin remodeling, RNAPII processing, nucleolin regulation, rDNA transcription ...
Abstract Transcription-coupled nucleotide excision repair (TC-NER) is a dedicated DNA repair pathway that removes transcription-blocking DNA lesions (TBLs). TC-NER is initiated by the recognition ...
as repair in which the ends of two DSBs are ligated without the utilization of homologous templates. Base damage, such as DHT, is mainly repaired by the base excision repair (BER) pathway [14], and SSBs ...
phosphodiesterase 1 Base excision repair PCNA: proliferating cell nuclear antigen POLD1: DNA polymerase delta 1, catalytic subunit PARP1: poly [ADP-ribose] polymerase 1 LIG1: DNA ligase 1 FEN1: Flap endonuclease 1 ...
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