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disorders. We aimed to comprehensively review the empirical literature on neurochemical actions of modafinil, and effects on cognition in animal models , healthy adult humans, and clinical populations. We ...
BackgroundSimultaneously with studies on animal models of fetal-induced maternal immune activation, related studies documented behavior, neurophysiological , and/or neurochemical disorders observed ...
a foundation for pursuing human pharmacological studies of PPI, and for extrapolating the substantial neurochemical and neurophysiological information from animal studies of PPI, towards understanding the neural ...
. Nature 1976;261:717-719.Crossref 39. McKinney WT, Moran EC: Animal models of schizophrenia . Am J Psychiatry 1981;138:478-483. 40. Davis M, Gendelman PM: Plasticity of the acoustic startle reflex ...
at Clinical High Risk (CHR-P) and predict clinical outcomes. Oxytocin, a neuropeptide with prosocial and anxiolytic properties, modulates glutamate neurotransmission in animals but its neurochemical effects ...
and pathophysiology of psychosis, especially regarding hippocampal-prefrontal-striatal network function and neural mechanisms of information processing and belief updating. schizophrenia , computational modeling ...
Abstract Psychiatric researchers need specific animal models to better understand the neurobiology of schizophrenia . Prepulse inhibition (PPI), the reduction in startle produced by a prepulse ...
in only a subset of rats, we hypothesized that these animals provide a valid model of susceptibility to schizophrenia to examine potential gene/environment interactions. In this work, we used this novel ...
interventions targeting cognitive symptoms in schizophrenia , neurophysiologic testing that provides a translational bridge between pharmacologic studies with animal models and clinical studies may better clarify ...
that ITC is decreased in patients with schizophrenia ,56 and in our work we could successfully model this circuit impairment in animals through a specific manipulation. The manipulation we performed did ...
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