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p38 MAPK is a conserved subfamily of MAPKs involved in inflammatory response, stress response, cell growth and survival , as well as differentiation of a variety of cell types. In this report we ...
during myelopoiesis through modulating C/EBPα transcriptional activity. 5 Open in new tabDownload slide p38 mitogen-activated protein kinase ( MAPK ) phosphorylates CCAAT/ enhancer binding protein α (C/EBPα ...
for JNKs, ERKs, and p38s respectively (1). Members of the ERK MAP kinase family primarily respond to cytokines, hormones and growth factors. In contrast, the p38 and JNK signaling pathways are often referred ...
]. These families can be divided into two groups: the classical MAPKs , consisting of ERK1/2, p38 , JNK and ERK5, and the atypical MAPKs , consisting of ERK3, ERK4, ERK7 and NLK (Fig. 1) [11]. The signalling pathways ...
assay was performed using recombinant p38 that had been activated by ZAP-70 (alternative pathway ) or MKK6 ( MAPK cascade). As substrate we used an NFAT1 fragment containing the first 350 amino acids ...
proliferation of Jurkat cells by the p38 pathway MAPK signalling pathways are pivotal for cell activation and proliferation. To examine the role of MAPK signal pathways in the cell proliferation of Jurkat cells ...
death was induced by GADD45A in HSCs, but a strong differentiation program via the initiation of the p38 MAPK signaling pathway . Forcing terminal differentiation of damaged hematopoietic stem ...
Kinase ( MAPK ) signaling . To explore this possibility, we overexpressed MAVS in HEK293 cells and then checked the activation of JNK, extracelluar signal -regulated kinase (ERK) and p38 . Interestingly ...
-dependent p38 signalling pathway . cytokine, p38 , p62, Paget's disease of bone , safety catch p62 has been initially identified as a phosphotyrosine-independent ligand for p56lck SH2 domain (1). This 440-amino ...
., Takagi M., Matsumoto K., Miyazono K., Gotoh Y. ( 1997 ) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways . Science 275 , 90 – 94 Google Scholar Crossref ...
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