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is mediated by the classical route of calpains and caspase 12 (maybe caspase 4 in humans) activated by the release of Ca from the ER; UPR-activated apoptosis also involves Jun kinase and C/EBP homologous ...
that the systems biology approach will bring valuable contributions to our understanding of regulations and mechanisms of the complex cell death pathways. yeast, programmed cell death, apoptosis systems biology ...
. This reduction may serve to protect the cell against a potentially lethal Ca2+ overload resulting from the increased activation rate in AF. Further, the review discusses the possible role of proteolytic systems ...
, whereas release of cytochrome c or apoptosis-inducing factor and intramitochondrial superoxide generation were suppressed. We also found that mitochondrial P5 was in close contact with citrate synthase ...
, mitochondrial permeability transition mediates apoptotic or necrotic stimuli and depends on the mitochondrial protein cyclophilin D. The third PN pathway involves the poly(ADP-ribose) polymerase- calpain axis ...
. Accelerated muscle atrophy and proteolysis in muscle-wasting conditions have been linked to oxidative stress and activated protease systems . Therefore, the hypothesis of this study was that proteolysis ...
, dsDNA, IFN-γ, etc. RIP1, RIP3, MLKL Necrostatin-1 (Nec-1), GSK-843, GSK-872, GSK-840, TAK-632, NTB451, necrosulfonamide (NSA) MPT-dependent necrosis Mitochondrial swelling/rupture, permeability of IMM ...
, whereas the peroxisome number remained unchanged in dog hepatocytes. Biochemical analysis showed that rat hepatocytes responded to PPAR agonists with an induction of both peroxisomal and mitochondrial β ...
by an increase in the proteins implicated in the endoplasmic reticulum protein-processing pathway and a decrease in mitochondrial proteins. Immunochemistry confirmed the presence of endoplasmic reticulum stress ...
attempted to provide a ‘bench‐to‐bedside’ continuum overview of head trauma research, an appreciation of the difficulties associated with research in this area and a book relevant to both basic researchers ...
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