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acting across both the inner and the outer membranes . Overproduction of efflux pumps alone or together with either modification of the outer membrane or antibiotic ‐inactivating enzymes and target mutations ...
, or if they are protected by other cell products (β-lactamases) or structures ( permeability barriers). Target modification can involve either reduced affinity of an existing PBP or the acquisition of supplementary β-lactam ...
modulating outer membrane fluidity and permeability in gram-negative bacteria. sRNAs involved in the regulation of membrane transporters The active pumping of antibiotics out of the cells by efflux pump ...
In Enterobacter aerogenes, multidrug resistance involves a decrease in outer membrane permeability associated with changes in an as yet uncharacterized porin. We purified the major porin from ...
that exhibit modified membrane permeability are highly prevalent. Interactions between antibiotic molecules and porin channels govern translocation efficiency. New physico-chemical techniques are being ...
impermeability. This study was undertaken to determine whether the outer membranes ofPseudomonas aeruginosa andPasteurella multocida can be rendered permeable to daptomycin by experimental modifications ...
, both screens identified genes involved in envelope homeostasis and membrane permeability . Our results also suggest that changes in the metabolism of S. Typhimurium induce the tolerance observed ...
and between patients. Diverse mechanisms of resistance, including antibiotic degradation, antibiotic target modification , and modulation of permeability through the bacterial membrane have been demonstrated ...
is a well described bacterial porin, which is localized in the outer membrane of Gram-negative bacteria, and plays a major role in antibiotic diffusion into the cell [24,36,38]. Interestingly, mutations ...
synthesized cyclic peptide antibiotic . The target of AS‐48 is the cytoplasmic membrane , in which it inserts in a voltage‐independent manner, forming pores and rendering the membrane permeable to small molecules ...
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