Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!
J, Albanell J, Molina MA et al. Mechanism of action of trastuzumab and scientific update . Semin Oncol . 2001 ; 28 (suppl): 4 –11. Crossref Search ADS 7 Herceptin package insert. San Francisco, CA ...
Table Open in new tab Mechanism of Action Trastuzumab is a recombinant humanized IgG1 monoclonal antibody against the extracellular domain of the HER‐2 receptor (ErbB‐2). The HER‐2 receptor consists ...
tabDownload slide ERBB2 signaling depicting actionable targets. Molecular mechanisms underlying resistance toward ERBB2 kinase inhibitors are schematically shown. Homo‐ and heterodimers involving ERBB2 ...
of trastuzumab and scientific update . Semin. Oncol. 28 : 4 – 11 . Google Scholar Crossref Search ADS PubMed WorldCat Bhattacharya-Chatterjee , M. , Chatterjee , S. K., Foon , K. A. ( 2001 ) The anti-idiotype ...
Abstract Somatic mutations in human epidermal growth factor receptor 2 (HER2) are present in approximately 3% of breast cancers. Some HER2 mutations are activating, and they represent a mechanism ...
. The combination of trastuzumab and pertuzumab has been shown to have synergistic antitumor effect in preclinical studies because of their different but complementary mechanisms of action [5]. The large, randomized ...
, Lofgren JA , Lewis GD et al. Nonclinical studies addressing the mechanism of action of trastuzumab (Herceptin) . Semin Oncol 1999 ; 26 : 60 – 70 . Google Scholar PubMed OpenURL Placeholder Text WorldCat 6 ...
with HER-2− tumors. However, does this imply that adjuvant trastuzumab therapy should be given to all patients with small HER-2+ tumors? I tend to disagree. Scientific evidence justifying the use of adjuvant ...
hour after a meal [1]. Mechanism of Action Lapatinib (Fig. 1A) is a potent reversible and selective inhibitor of the intracellular domains of the tyrosine kinases EGFR (HER-1) and HER-2. It competes ...
cancer, HER‐2‐directed therapy, HER‐2‐positive, Trastuzumab , Lapatinib, T‐DM1, Pertuzumab Implications for Practice: HER‐2‐directed therapy remains one of most promising areas of development ...
Access the full text.
Sign up today, get unlimited access with DeepDyve Pro!