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to the nucleus, and activation of Wnt signalling target genes immediately following Apc loss , thus supporting the model that Apc loss , and deregulation of Wnt signalling, is one of the earliest events during ...
Introduction Tumors arise from normal cells upon an accumulation of alterations, including genetic and epigenetic loss -of-function events affecting tumor suppressor genes and gain-of-function events ...
-canonical P53 REs consisting in three-quarter sites ( one decamer plus an adjacent half decamer) or in half-sites (a single decamer) can also mediate P53 binding and gene responsiveness. Tebaldi et al. (2015 ...
. For pathway analysis, we used an in-house generated list of genes (see online supplemental material) associated with the Wingless/Integrated (WNT), Tumor Protein p53 signalling (TP53), and Nuclear factor kappa ...
within this locus have emerged as major tumor suppressor genes , ranking in importance with the retinoblastoma gene (RB1) and the p53 gene (TP53). The INK4A-ARF locus encodes two potent inhibitors ...
senescence in these cells remains unclear. Increased expression of p16 with increasing passage level has been observed consistently, but variable or falling expression of p53 -activated genes p21 and p27 has ...
carcinoma by regulating TGM5 expression [8]. In contrast, this association is hypothesized to be through the function of TP53BP1 ( tumor protein p53 binding protein 1) due to the position (~226.1 kb away from ...
by concurrent beclin 1 knockdown, suggesting dependence on autophagy induction and progression [16]. p53 , the most extensively characterized tumor suppressor, is a master regulator with pleiotropic effects ...
resistance. One study detected intragenic PTPRS deletion in 26% of HNSCC tumors , resulting in loss of mRNA expression and promoting EGFR/PI3K pathway activation [71]. Moreover, in vitro results showed ...
to significant limb paralysis and loss of sensation. Second, tumor cells can acquire further mutations in key genes such as p53 that may result in transformation of the pNF into a malignant peripheral nerve sheath ...
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