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Journal club Editors Age of transfused blood: An independent predictor of mortality despite universal leukoreduction. J.A. Weinberg, G. McGwin Jr, R.L. Griffen et al. J Trauma 65:279-284, 2008 Both the effect of the age of blood and leukoreduction on outcomes have been controversial. Weinberg et al combine these 2 hot topics in their analysis of trauma patients. The authors report a retrospective analysis of trauma patients at their hospital from 2000 through 2007. Of note, patients who died within 24 hours of admission were excluded. The number of units (all leukoreduced) received during the first 24 hours was divided into those that were less than 14 days old and those that were more than 14 days old. The authors chose this number as they cite several retrospective articles from a single group suggesting that 2 weeks may be an appropriate cutoff for the deleterious effects of blood transfusion. The authors present odds ratios (ORs) for the risk of death adjusted for age, sex, injury severity score (ISS), mechanism of injury, total number of units in the first 24 hours, and length of hospital stay. It appears that any adjustments made for the number of units transfused were based on stratification http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Transfusion Medicine Reviews Elsevier
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