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Patients with myelodysplastic syndrome (MDS) frequently receive red blood cell (RBC) transfusions for anaemia resulting from ineffective erythropoiesis. While RBC transfusions may rapidly increase ...
The International Prognostic Scoring System (IPSS) and karyotype are useful tools for risk stratification in primary myelofibrosis (PMF). We examined the additional prognostic impact of red blood ...
and evolution to acute myeloid leukemia. Iron overload is a serious complication in patients with MDS due to the long-term use of red blood cell transfusions in patients with symptomatic anemia. Clinical ...
. Introduction Transfusion ‐related iron overload (TRIO), also referred to as transfusional iron overload , occurs when red blood cell (RBC) transfusions are given in the absence of iron deficiency [1]. Each unit ...
Many patients with primary myelofibrosis (PMF) become red blood cell (RBC) transfusion dependent (TD), risking iron overload (IOL). Iron chelation therapy (ICT) may decrease the risk ...
blood cell transfusions and iron overload in the treatment of patients with myelodysplastic syndromes . Cancer . 2008 ; 112 : 1089 – 95 . Google Scholar Crossref Search ADS PubMed WorldCat 2 Greenberg PL ...
oxygen delivery to tissues. Complications of Transfusions Blood transfusions come with risks, such as procedural problems, iron overload , possible viral and bacterial infections, direct immune injury ...
, there is increasing evidence to suggest that intraoperative blood transfusions increase risk11, and lead to a dose-dependent increase in morbidity and mortality2. Even a single unit of transfused red blood cells (RBCs ...
of diminished erythropoiesis ( red blood cell formation) in the bone marrow due to exposure to certain drugs or toxins, nutritional deficiencies of substrates required for erythropoiesis (e.g., iron , folate ...
correction of anaemia, and there was a dramatic fall in both the use of red cell transfusions in dialysis units, as well as the associated transfusional iron overload prevalent in dialysis patients. Avoidance ...
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