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Journals Biochemical and Biophysical Research... Volume 417 Issue 1

Highlights ► We describe the binding site of Auranofin (AF) for Sm TGR, an S. mansoni vital enzyme. ► We confirm a molecular mechanism for the Sm TGR inhibition by AF. ► We provide a model for Pf TR, the P. falciparum homologous of Sm TGR. ► We illustrate the results of an analysis of the putative interaction of AF with Pf TR. ► We conclude that Pf TR is likely to be the target for AF in P. falciparum.

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Investigation of a potential mechanism for the inhibition of Sm TGR by Auranofin and its implications for Plasmodium falciparum inhibition

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  • Publisher Elsevier
  • Copyright Copyright © 2011 Elsevier Inc.
  • ISSN 0006-291X
  • D.O.I. 10.1016/j.bbrc.2011.12.009
  • Publisher site Get PDF  

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